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We hypothesized that female sex hormones affect RXFP1 and RXFP2 expression in the patellar tendon and lateral collateral ligament, thus affecting knee laxity. This could explain differences in the incidence of non- contact knee injury between male and female , and in female at different phases of the menstrual cycle . In view of this, we investigated these isoforms expression in the patellar tendon and lateral collateral ligament in rat model in order to provide the mechanism underlying changes in knee laxity under different sex-steroid influence..
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